Zinedine Zidane somewhat surprisingly started Marco Asensio and Lucas Vazquez on the wings and the two combined to set up Ronaldo for the killer goal in the second half, as the Portugal star kept up his run of scoring in every game in this season's competition.
Paris Saint-Germain will attempt to overturn a 3-1 deficit when they host Real Madrid in their heavyweight Champions League last-16 second leg on Tuesday (21:45 SA time), but do so without the injured Neymar.
The club insist they are not worried about falling foul of UEFA's Financial Fair Play rules, even if a premature European exit will mean a shortfall of millions of euros.
"What makes me proud is seeing everybody's efforts".
The result restores PSG's 14-point lead over reigning champions Monaco at the top of the table with just nine games left, keeping them on course to reclaim the title.
France forward Kylian Mbappe hit PSG's fourth in first half stoppage time, while captain Thiago Silva completed the rout with a towering header from a corner in the 82nd minute.
"It's going be difficult and we are going to face big teams from now but we keep working to achieve big things".
"We are relaxed about it. It is more of an issue outside the club than inside".
Manager Unai Emery appears to be on the brink and has come under fire from one of his own players after attacker Julian Draxler went public following his exclusion from the last 16 tie on Tuesday night.
Cristiano Ronaldo and Casemiro scored for the defending European champions.
"PSG is a sound project".
In a poll on Mundo Deportivo's website, Barcelona fans made their feelings clear with 69% of 5,000 voters saying they would not bring him back to Catalonia, compared to 31% of readers who would.
Emery's contract expires in June and it seems highly unlikely he will get another one.
Marquinhos, another Brazilian, appears to be a surer defender and is 10 years younger. Mendilibar's side put five past a disinterested Sevilla a few weeks ago and held Zidane's team in the Bernabeu last season. "We need to calm ourselves and think about how we can improve the team". It's Champions League and the whole world is watching.
As fans we ingest the optimism galvanised by PSG's wonderfully creative social media team.
City really struggled to cope with the 23-year-old and his trickery in one v one situations really caught the eye - the winner exemplifying his talent.
Zidane told a press conference: "Gareth is not lacking anything".